Stanford University
This application to renew participation in the renamed Chronic Pancreatitis Clinical Research Consortium (CPCRC) (formerly called the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreas Cancer [CPDPC]), will enable the Stanford Clinical Center to continue its productive recruitment and retention of patients into 2 clinical studies of the consortium – 1) Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED), and 2) Pediatric Longitudinal Cohort Study of Chronic Pancreatitis [The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE2).
Prospectively collected specimens from these studies will be used to further examine the role of the immune system in recurrent acute pancreatitis and chronic pancreatitis with clinically relevant outcomes. As part of the original Consortium, the Stanford Clinical Center has demonstrated the capacity to effectively recruit and retain patients into 2 primary studies of the CPCRC. We have successfully used prospectively collected samples from the PROCEED cohort to demonstrate key immune signaling pathways to diagnose chronic pancreatitis. In response to the research objectives of the CPCRC as outlined in this RFA, we have formed a strong scientific team with broad complementary expertise in clinical adult and pediatric pancreatitis, endocrinology, radiology, and immunology.
In this renewal, we intend to validate these findings and characterize predictive immune signatures of chronic pancreatitis and relevant clinical outcomes with 3 proposed ancillary studies – one of which will use serially collected samples over time for the same patient.
We also propose a proof-of-concept immune-based clinical trial to repurpose a commercially available FDA-approved IL-17 inhibitor to prevent the progression of recurrent acute pancreatitis to chronic pancreatitis.
Public Health Relevance Statement
The Stanford Clinical Center will continue to lead and actively participate in the research objectives of the Chronic Pancreatitis Clinical Research Consortium (CPCRC) by recruiting into the 2 key clinical studies and adult and pediatric chronic pancreatitis. Collected specimens from these studies will be studied to develop and validate new immunological insights into how chronic pancreatitis progresses and its complications. These insights will inform new diagnostic tests and treatments.
